"Wild Saccharomyces does not make any of these compounds. If it had acquired the trick of making opiates in its evolutionary past, palm wine drinkers would have bathed their nerve endings in such tranquilizing spirits that early Homo sapiens would have sleep-walked itself into the fossil record."

[on using Yeast to manufacture opiates]
The Rise of Yeast: How the Sugar Fungus Shaped Civilization  - Nicholas P. Money

Nicholas P. Money in The Rise of Yeast:  How the Sugar Fungus Shaped Civilization (2018)